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SLU-PP-332 is a synthetic small-molecule agonist of estrogen-related receptors alpha and gamma (ERRα/ERRγ) — nuclear receptors that function as master transcriptional regulators of mitochondrial biogenesis, oxidative metabolism, and fatty acid oxidation gene programs — designed to pharmacologically mimic the metabolic adaptations of endurance exercise at the cellular level
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Now, published in Scientific Reports , Watowich and colleagues from the University of Texas Medical branch show that treating with 5-amino-1MQ improves grip strength to a greater degree than rigorous exercise in aged mice
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