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Targeting CCR1-mediated macrophage phenotypic switching to alleviate bladder pain and urinary dysfunction in interstitial cystitis | Communications Biology

Excessive astrocytic GABA synthesis and release lead to abnormal synaptic transmission and cognitive deficits

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At the same time, AOD‑9604 also showed fat-burning effects even in models lacking these receptors, suggesting it may activate additional pathways involved in energy use and fat oxidation