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Then, an aqueous solution of NaOH (1 M, 0.15 mL) was injected into the reacting solution, followed by stirring

C-KACKIEAOS-D-100

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(1.2) Pemetrexed Dosage and Administration • The recommended dose of pemetrexed for injection administered with pembrolizumab and platinum chemotherapy in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m2 as an intravenous infusion over 10 minutes, administered after pembrolizumab and prior to platinum chemotherapy, on Day 1 of each 21-day cycle