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From a mean baseline body weight of 101 kg, patients receiving the higher CagriSema dose achieved a superior 14.2% reduction in body weight after 68 weeks compared with 10.2% with semaglutide 2.4 mg
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Studies have shown that activation of Wnt/β-catenin pathway can promote cytoskeletal recombination and new blood vessel formation of endothelial cells, possibly through promoting the expression of VEGF and MMPs (96, 97)
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