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Key findings from preclinical research include: Reduced body weight and body fat in obese mice following 14 days of chronic administration Increased lipolytic sensitivity in adipose tissue Enhanced fat oxidation without changes in food intake Preservation of lean body mass during weight loss No evidence of systemic toxicity or adverse metabolic effects Importantly, studies in beta-3-AR knockout mice revealed that while the beta-adrenergic pathway contributes significantly to AOD9604 ‘s effects, alternative mechanisms also participate in fat reduction, suggesting a robust and redundant system for lipid mobilization