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However, it is also possible that cholecystokinin, glucagon-like peptide-1, and peptide YY, which are released from enteroendocrine cells and are associated with nausea and/or emesis, may also have a local effect on vagal afferents and/or the AP ( After a “high” cisplatin dose, released inflammatory mediators (e.g., prostaglandins, bradykinin) may sensitize afferents so that stimulation thresholds are reduced (Rudd et al., 1994)

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