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Compared to Tf, Lf was shown to be apically internalized into Caco-2 intestinal epithelial cells and then localized to the nuclei while Tf was internalized from the basolateral side and localized in the cytoplasm [205]

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Likewise, SQSTM-1/p62 identifies ubiquitinylated proteins to assist in their removal, and it is also broken down during the process of autophagy