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The first description of cyanide poisoning was by Wepfer in 1679 and dealt with the effects of the administration of extract of bitter almonds (Sykes, 1981)
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Mechanistically, HGF inhibits inflammatory M1-like macrophage production of pro-inflammatory cytokines and chemokines (such as IL-1β, IL-6, TNFα, CXCL1, CXCL10, and CCL2) by disrupting nuclear factor NF-κB signaling (Kamimoto et al., 2009a,b
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