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Concurrently, hypoxia regulates redox homeostasis, autophagy, angiogenic signaling (including VEGF induction), epithelial–mesenchymal transition, stemness, and extracellular matrix remodeling—collectively fostering invasion, metastasis, immune evasion, and resistance to radiotherapy, chemotherapy, and immunotherapy

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Habiballa L, Salmonowicz H, Passos JF