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Changes in expression and distribution of claudin 2,5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease
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The landmarks are outlined by a marking pen: Greater trochanter Posterior superior iliac spine Needle insertion site 4 cm distal to the midpoint between the two landmarks Technique The patient is in the lateral decubitus position with a slight forward tilt–this prevents the “sag” of the soft tissues in the gluteal area and significantly facilitates block placement
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