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3.2 S-glutathionylation - endoplasmic reticulum proteins As the organelle responsible for folding of newly synthesized, secreted and membrane-bound proteins, the ER maintains a redox homeostasis that is shifted toward a more oxidized state when compared to the remainder of the cell

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Discussion ROS-induced signals regulate B cell activation and early metabolic reprogramming 97,98 , and a flexible redox system controls B cell differentiation 31,99,100