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Figure 3 2.5 The CXCL17/CXCR8 chemokine/receptor pair regulates effector and regulatory CD4 + and CD8 + T cells trafficking and localization into inflamed and infected mucosal tissues Studies have shown that GPR35 activation can stimulate the production of pro-inflammatory cytokines and facilitate the movement of immune cells, including effector CD4 + and CD8 + T RM cells, towards inflammatory and infected mucosal tissues of gastrointestinal tract, respiratory tract, and female genital tract ( reg cells) ( Later, in 2018, we reported that CXCL17 is involved in the recruitment of CD8 + T cells that mediate protective immunity against sexually transmitted herpes infection ( i ) it is widely present in more than 3.7 billion people worldwide and ( ii ) it is becoming an increasingly common cause of genital infection, mainly in developed countries ( + CD8 + T cells in the female genital tract, and that this recruitment was associated with protection against genital herpes infection and disease