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Has been shown to inhibit NF-κB, possibly through inhibition of JNK (IC 50 =10µM), the COP9 signalosome kinase (IC 50 =10µM) and p300/CBP
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On the contrary, alterations in the C-terminal seemed less critical for activity and for instance a deletion of the C-terminal phenylalanine residue of 1 had only a minor impact and the binding affinity was essentially maintained (Sardinia et al., 1993
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