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Given that hypertension has a complex multifactorial etiology, these polymorphisms may represent only one element in disease development

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Mast cells release histamine and other mediators that recruit immune and endothelial cells to the wound site, thus initiating tissue remodeling and vascular response.² Thymosin Beta-4 Fragment (17–23) is also linked to angiogenesis, likely through indirect stimulation of vascular endothelial cells