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In this same study, TYK2 knockdown in EndoC-BH1 and primary human islet cells decreased apoptosis, STAT1 and STAT2 phosphorylation, IFNα and CXCL10 secretion, and class I HLA protein expression (67)

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According to GLOBOCAN 2020, a project of the International Agency for Research on Cancer (IARC), it was estimated that there were over 19.3 million new cancer cases and 10 million deaths in 2020 (Figure 1)