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During EAO CD4 + T cells, especially Th1 and Th17 populations, are activated and enriched in the testis, where they secrete IFN-γ, IL-1, IL-6 and other inflammatory cytokines that both directly injure the seminiferous epithelium and drive B cells to produce ASA, thus worsening tissue damage and dysfunction (153)

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[DOI] [PubMed] [Google Scholar] 227.Derosa G., Cicero A.F., Fogari E., D’Angelo A., Bonaventura A., Maffioli P