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Such dysregulation may entail disrupted glutamine homeostasis, perturbed uptake or metabolism of glutamate and GABA, or a more generalized metabolic dysfunction
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The HPLC method for derivatization, separation, and quantification of methionine and cysteine content was performed essentially as previously described ( ® 5 µm RP-18 100 Å, 250 × 3 mm ID column connected to an HPLC system from Agilent in combination with a fluorescence detector from Shimadzu
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