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Glutamate induces myelination of axons and it is therefore not surprising that white matter and myelin abnormalities are frequently reported in patients with an inborn error of glutamate metabolism.2 Although this is an a‐specific sign seen in many disorders, it is more prevalent in glutamate related disorders than in all Mendelian disorders (14‐16×) and in all disorders with metabolic abnormalities (9‐13×)
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