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Methylation is essential for the activity of HNMT, one of the two primary enzymes responsible for histamine degradation
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Systematic reviews of oral vitamin B12 therapy in vitamin B12 deficiency The first evidence-based analysis by the Vitamin B12 Cochrane Group in 2005 supports the efficacy of oral vitamin B12 as a curative treatment, with a dose between 1,000 and 2,000 µg (1 and 2 mg) initially prescribed daily and then weekly [27]
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