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Treatment with 30 mg/kg and 100 mg/kg i.p., or 500 mg/kg orally (p.o.), significantly increased time spent in the open arms of the elevated maze, comparable to diazepam and buspirone

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The process begins when active folate, known as L-5-methyltetrahydrofolate (L-5-MTHF), donates a methyl group to cobalamin, transforming it into methylcobalamin