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Disclosure : Nothing to declare 15: Paediatrics – Clinical P750 BUSULFAN ASSOCIATED PULMONARY TOXICITY AND INFECTIOUS COMPLICATIONS FOLLOWING AUTOLOGOUS SCT IN A 3-YEAR-OLD CHILD WITH NEUROBLASTOMA Ines Goppelt 1 , Maria Polacik 1 , Heike Schützle 1 , Sebastian Brenner 1 , Christian Vogelberg 1 , Kristina Stamos 1 , Christoph Meißner 1 , Reinhard Berner 1 , Denis Martin Schewe 1 1 University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany Background : High-dose busulfan/melphalan (Bu/Mel) remains a standard conditioning regimen for autologous stem cell transplantation in high-risk neuroblastoma but is associated with significant organ toxicity, particularly hepatic and pulmonary injury