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How GHK-Cu Works in Skin at the Molecular Level The glycyl-L-histidyl-L-lysine tripeptide forms a high-affinity complex with copper(II) ions, creating the active GHK-Cu complex that functions as a biological signal molecule rather than a structural component

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While specific information on mechanisms by which MGST1 activation proceeds are presently undefined, these are known to involve a higher rates of formation of the GSH thiolate anion within the activated enzyme (Andersson et al., 1994