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Cycled topical actives such as retinoids, vitamin C, and niacinamide are sometimes paired with GLOW during the active weeks

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The intracellular signaling cascades activated during dosing — PI3K/Akt/mTOR for synthesis, FoxO suppression for anti-catabolism — do not terminate immediately when plasma LR3 clears (Yoshida & Delafontaine, 2020)