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However, in a similar anatomical study of neurons in the locus coeruleus little or no loss of receptors was found after chronic morphine treatment (Van Bockstaele and Commons, 2001), but acute administration of morphine did induce internalization in the dendrites of neurons in the nucleus accumbens when measured with immuno-electron microscopy (Haberstock-Debic et al., 2003)

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They appear most strongly during the first 1-2 weeks after each dose increase, then gradually subside as your body adapts to the new level of receptor activation