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In the acute COVID-19 context, previous studies have demonstrated that vitamin B12 increases the flow of the sulfur amino acid pathway, favoring production of glutathione, an important antioxidant agent, in leukocytes of patients with moderate and severe COVID-19 18

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Introduction and Scientific Context 1.1 The Need for Covalent Capture Tools in Chemical Biology The study of protein–protein interactions (PPIs) and the identification of molecular targets of bioactive small molecules are among the most impactful and technically challenging objectives in modern chemical biology and drug discovery