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It has been suggested that GPx4 might utilize either the “low-oxidation” (R-SeO-) or the “high-oxidation” (R-SeOO) cycle, depending on cellular conditions

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TM6 undergoes the characteristic outward rotation that opens the G protein-binding cavity, TM5 repositions to form the lateral wall of this cavity, and the intracellular ends of TM3 and TM7 reorganize to complete the G protein docking surface