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These include regulation of mechanisms controlling reactive oxygen species (ROS), which cause macromolecular damage 16,17 , mitochondrial turnover or mitophagy 18 , and the mitochondrial unfolded protein response (UPR mt ), in which mitochondrial damage can be prevented by the removal of aggregated or unfolded proteins 19

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[DOI] [PubMed] [Google Scholar] 56.Heil S.G., de Jonge R., de Rotte M.C., van Wijnen M., Heiner-Fokkema R.M., Kobold A.C., Pekelharing J.M., Adriaansen H.J., Sanders E., Trienekens P.H., et al