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Mancin and collaborators showed that α-lipoic acid polymerization could be realised through a single-step synthesis using 1-octanethiol as initiator, producing cross-linked poly(α-lipoic acid) nanoparticles loaded with dye and protected by PEG directly from small molecule precursors [196]
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Clearance is the most important pharmacokinetic parameter because it is the only parameter that controls overall drug exposure and it is used to calculate the dosage required to maintain a specific average steady-state concentration
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