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PPARs play a role in inflammation by reducing the levels of cytokines such as interleukin 6 (IL-6), IL-1β, and TNF-α in liver tissues (121)

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Concomitantly, other cytokines such as IL-1α and β, IL-10, IL-6, and others exhibited lower concentrations in Mda5 -/- bone marrow serum, while other cytokines like TNF and IFNγ showed no differences (Fig