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Targeting energy pathways in kidney disease: The roles of sirtuins, AMPK, and PGC1α

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under this normalization, LMG remained significantly higher than STD for both iAUC and ΔC max ( p = 0.0040 and p = 0.0003), corresponding to approximately up to 4-fold higher exposure and peak response at the 300 mg equivalent (Table 2)