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These results led to the development of the ortho -carborane building block 9-(carboxymethylthio)-1,2-dicarba- closo -dodecaborane(12) and a deoxygalactosyl-functionalized, charge-compensated cobalt bis(dicarbollide) building block, which were introduced at position 4, 18, or 22 of [F 7 ,P 34 ]NPY by the side-chain of substituted lysines at the respective positions (Ahrens et al., 1 R and selectivity against other hYR subtypes and the sufficient uptake into hY 1 R transfected HEK293 cells was proven
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Similarly, 10µM of BAY 43-9006 significantly induced hemolysis exclusively in Ringer at 0.4% hematocrit ( p =0.0012), but not in Ringer at 4% hematocrit or in cRPMI at 4% hematocrit
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