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Plasma levels decline significantly with age, from approximately 200 ng/mL at age 20 to around 80 ng/mL by age 60, which has made it a focus of anti-aging skincare research

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This can show up as symptoms such as delayed growth and development (failure to thrive), regression in neuromotor skills (such as losing the ability to roll over or grasp objects), failure to maintain eye contact (even in an infant who previous could do so), general muscle weakness, lethargy, excessive sleepiness, feeding difficulties, and even brain shrinkage