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Although previous evidence suggests that different molecular mechanisms underlie glutamate-induced phase shifts at early and late subjective night (Golombek & Rosenstein, 2010), the NDMAR appears to be involved in both copper chelation-induced phase shifts at both time points (Yamada & Prosser, 2014)

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6.1.1 Neuroimmune pathways Intestinal I/R injury induces ischemic damage to the gut, leading to the activation of immune responses within the gut mucosa