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Clinical trials guiding evidence for treatment are lacking due to the rarity of disease, heterogeneous clinical course, and lack of prognostic biomarkers, all of which contribute to difficulty in clinical trial design and implementation

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Although the cryo-EM map was determined at medium resolution, we could build a reliable model by fitting the crystal structures of NK1 dimer as well as the SEMA, PSI, IPT1, and IPT2 domains of c-MET into a cryo-EM map with minor adjustment 24,30 (Supplementary Fig