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Cytokine quantification Cytokine concentrations in culture supernatants and BALF samples were quantified using either LEGENDplex Mouse Th Panel or LEGENDplex Human Th2 Panel (BioLegend) per the manufacturer’s instructions and described previously (71, 73, 75, 76)

Serum glutathion

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Maintaining cellular NAD⁺ supports mitochondrial function, stress resilience, and metabolic flexibility—key mechanisms linking NNMT inhibition to improved energy balance (Kannt & Pfenninger, Frontiers in Physiology )