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With the recognition that local tissue RASs exist has come research interest in additional physiological and pharmacological functions that permit better understanding of clinical dysfunctions such as inflammation, cellular proliferation, apoptosis, and fibrosis accompanied by an increased appreciation for the role of both the AT 1 and AT 2 receptor subtypes [reviewed in Ref

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Intricacies of TGF-β signaling in Treg and Th17 cell biology