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Footnotes Edited by: Bernd Rosenkranz, Fundisa African Academy of Medicines Development, South Africa Reviewed by: Kacper Nijakowski, Poznan University of Medical Sciences, Poland Miriam Njoki Karinja, Science for Africa Foundation, Kenya Data availability statement The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author

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596 Notably, memory loss in the PS2APP mouse AD model has been linked to astrocyte Ca 2+ hypoactivity due to reduced expression by astrocytes of the calcium sensor, STIM1