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Large extraparenchymal arteries, including the vessels of the circle of Willis and major pial arteries, possess a well-developed tunica media with multiple layers of smooth muscle (ranging from ∼20 layers in the internal carotid artery to 2–3 layers in smaller pial arteries) and a prominent internal elastic lamina ( Penetrating arterioles, which branch from pial vessels within the Virchow-Robin space, exhibit fewer layers of smooth muscle and reduced elastic structures, marking the transition toward greater local control ( 2 and K + and play a larger role in NVC and CVR