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This includes encouraging adherence to the Mediterranean diet (MedDiet), which is abundant in carotenoids, polyphenols, fiber, and polyunsaturated FAs, while avoiding refined and high-sugar foods

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However, an overproduction of probiotic metabolites like peptidoglycan fragments or bacterial DNA can hyperactivate DCs via TLR2/9 or NOD2, boosting BAFF/APRIL production via NF-κB/MAPK pathways, potentially triggering systemic autoreactive B cells and exacerbating SLE autoimmunity (139–141)