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For example, CRISPR activation (CRISPRa) was used to direct dCas9 to the promoter region of the KCNA1 gene to increase protein expression of the associated K v 1.1 potassium channel subunit (Colasante et al., 2020a), as reduced expression or dysfunction of K v 1.1 has been implicated in several forms of epilepsy
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