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Acetylcholine is responsible for mood regulation, psychomotor activity, and sleep (438), by activation of central muscarinic receptors, rather than nicotinic receptors (153)

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Furthermore, after 3 weeks of HIIT training, the CD4/CD8 T cell ratio in peripheral blood was significantly increased compared to moderate-intensity training, suggesting that HIIT may be more effective than sustained moderate-intensity exercise in regulating immune cell ratios and reducing inflammation (111)