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The primary endpoint was the mean change in HbA1c from baseline to week 52 for tirzepatide relative to insulin lispro ( 4.7 SURPASS J-mono trial in Japan In Japan, the SURPASS J-mono trial enrolled 636 Japanese adults with type 2 diabetes (age ≥20 years) who discontinued oral monotherapy or were treatment-naive due to hyperglycemia ( 4.8 SURPASS J-combo trial in Japan The SURPASS J-combo trial included 443 Japanese adults with type 2 diabetes (age ≥20 years, BMI ≥23 kg/m 2 , inadequately controlled HbA1c), who received tirzepatide 5 mg, 10 mg, 15 mg in addition to oral antidiabetic drugs for ≥3 months
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Nevertheless, after intervention with GHK-Cu, a significant reduction in these pathological changes was observed (Figures 2D–G)
