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For instance, in a placebo-controlled, double-blinded, randomized, phase 2 study (NCT03840005), the effect of Ursodeoxycholic acid (UDCA) on mitochondrial bioenergetics was found to be well tolerated in control and PD patients and evidenced increased ATP hydrolysis along with improved motor symptoms

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In certain models, it appears to influence fibroblast activity, collagen production, and glycosaminoglycan synthesis